Welcome MultiPole

Programme

Sunday Monday Tuesday Wednesday

Sunday, May 10

14:00 - 17:00	Registration (at the Staszic Palace)
17:00 – 18:00	Opening remarks from distinguished organizers, sponsors, and guests Chair: Janusz Lipkowski
18:00 – 19:00	Session I: History of macromolecular crystallography Chair: Wladek Minor Alexander Wlodawer National Cancer Institute, Frederick, MD, USA A very abbreviated history of macromolecular crystallography Zbigniew Dauter National Cancer Institute, Argonne, IL, USA Multipoles through the looking glass
19:00 – 21:00	Beer and wine

Monday, May 11

8:30 – 9:15	Opening Lecture Chair: Joanna Trylska Ada Yonath From Zdunska Wola to Warsaw with the Ribosome
9:15 – 9:30	Break
9:30 – 12:00	Session II (Part 1): Proteins and nucleic acids Chair: Marcin Nowotny Matthias Bochtler International Institute of Molecular and Cell Biology, Warsaw, Poland Institute of Biochemistry and Biophysics, Warsaw, Poland A structural biologist's view of DNA methylation and hydroxymethylation. Witold Filipowicz Friedrich Miescher Institute of Biomedical Research, Basel, Switzerland Structural insights to the role of the CCR4-NOT complex and GW182 and DDX6 proteins in miRNA-mediated repression Andrzej Dziembowski Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland Institute of Genetics and Biotechnology, University of Warsaw Architecture of the CCR4-NOT complex from Schizosaccharomyces pombe, a multifunctional cellular machine Joanna Trylska University of Warsaw, Poland Interactions of aminoglycoside antibiotics with RNA Mariusz Jaskólski Adam Mickiewicz University, Poznań, Poland Polish Academy of Sciences, Poznań, Poland Tema con variazioni: modulated structures of Hyp-1 complexes
12:00 – 13:00	Lunch break
13:00 – 14:50	Session III (Part 1): Modeling and theoretical studies Chair: Witold Filipowicz Andrzej Kolinski University of Warsaw, Poland Towards unrestrained protein-protein molecular docking Janusz Bujnicki International Institute of Molecular and Cell Biology, Warsaw, Poland Adam Mickiewicz University, Poznań, Poland Coarse-grained modeling of 3D structure for RNA and macromolecular complexes Marta Szachniuk Poznan University of Technology, Poland Institute of Bioorganic Chemistry, Poznań, Poland RNApdbee and assessing the RNA secondary structure Marek Cieplak Institute of Physics, Polish Academy of Science, Warsaw, Poland Structure-based models of proteins in action: virus capsids, proteins with cavities, unfolding by proteasomes, formation of knots
14:50 – 15:15	Coffee Break
15:15 – 16:00	Iain Mattaj – Special Speaker EMBL - Europe's flagship laboratory for the life sciences and its role in structural biology
16:00 – 17:30	Panel Session – Accession of Poland to EMBL Chair: Andrzej Legocki Participants: Iain Mattaj, Leszek Kaczmarek, Mariusz Jaskolski, Prof. Wlodzislaw Duch, Maciej Zylicz, Jerzy Duszynski
17:30 – 18:50	Session IV: Large and challenging structures Chair: Matthias Bochtler Zygmunt Derewenda University of Virginia, Charlottesville, VA, USA The structural biology of Ca²⁺-independent modulation of smooth muscle contraction Jolanta Grembecka University of Michigan, Ann Arbor, MI, USA Structure-based development of menin-MLL inhibitors for cancer therapy. Pawel Grochulski Canadian Light Source Inc., Saskatoon, SK, Canada College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada Crossing membranes: beta-cyclodextrin-gemini surfactant and the type II secretion system
19:00 – 21:00	Social program

Tuesday, May 12

8:30 – 11:10	Session III (Part 2): Modeling and theoretical studies Chair: Miroslaw Cygler Adam Godzik Sanford-Burnham Medical Research Institute, La Jolla, CA, USA Understanding cancer mutations with protein and network modeling Janusz Lipkowski Cardinal Stefan Wyszyński University, Warsaw, Poland Hydration patterns in supramolecular systems Krzysztof Woźniak University of Warsaw, Poland Crystallography beyond Independent Atom Model Piotr Setny University of Warsaw, Poland From hydration free energies to localised water molecules - a novel, semi-explicit hydration model Joanna Sulkowska University of Warsaw, Poland New complex topology in proteins and evolutional analysis of their origin Wieslaw Nowak Nicholas Copernicus University, Toruń, Poland How to navigate inside protein tunnels - lessons from nature
11:10 – 11:30	Coffee Break
11.30 – 12:20	Session II (Part 2): Proteins and nucleic acids Chair: Jolanta Grembecka Marcin Nowotny International Institute of Molecular and Cell Biology, Warsaw, Poland The mechanism of structure-selective nucleases in DNA repair Waldemar Priebe University of Texas MD Anderson Cancer Center, Houston, TX, USA Bench-to-Bedside Design, Synthesis, Evaluation, and Development of Novel DNA Binding Agents
12:20 – 13:20	Lunch Break
13:20 – 15:35	Session IV (Part 1): Methods and their improvement Chair: Zbyszek Dauter Wladek Minor University of Virginia, Charlottesville, USA Protein Crystallography with Speed and Finesse Dominika Borek University of Texas Southwestern Medical Center, Dallas, TX, USA Solving structures from very low resolution data Maria Gdaniec Adam Mickiewicz University, Poznań, Poland Exploring the wealth of specific intermolecular interactions for crystal engineering Andrzej Joachimiak Argonne National Laboratory, Argonne, IL, USA University of Chicago, Chicago, IL, USA Structural Biology Using Light Sources Helps Combat Infectious Diseases and Antibiotic Resistance Tadeusz Skarzynski Agilent Technologies, Oxford, United Kingdom Structural biology in drug discovery: current strategies and challenges
15:35 – 15:50	Coffee Break
15:50 – 18:00	Session IV (Part 2): Methods and their improvement (continued) Chair: Zbyszek Dauter Piotr Neumann University of Göttingen, Germany Multi-resolution refinement and fitting of atomic models into cryo-EM reconstructions Zbyszek Otwinowski University of Texas Southwestern Medical Center, Dallas, TX, USA Advanced methods for molecular replacement. Agnieszka Pietrzyk Freie Universität Berlin, Germany Identification of amino acid sequence by X-ray crystallography: crystal structures of silkworm proteins as case studies Urszula Rychlewska Adam Mickiewicz University, Poznań, Poland Chiral, Shape Persistent Molecules as a Source of Inclusion and Microporosity in Crystals Zbigniew Kaszkur Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland True nanocrystallography
18:00 – 20:00	Poster Session and Oral Presentations by the Sponsors
18:00 – 18:20	Piotr Wardęga NanoTemper Technologies GmbH Quantitative analysis of biomolecular interactions with Microscale Thermophoresis (MST)
18:20 – 18:40	Mariusz Milik Head of Computational Chemistry, Selvita S.A. Computer-aided Biotechnology: Example of Selvita S.A.

Wednesday, May 13

8:30 – 10:20	Session V: Signaling, transport, and immunology Chair: Andrzej Joachimiak Andrzej Marek Brzozowski University of York, United Kingdom Insulin: molecular fossil or hormonal maverick? Maksymilian Chruszcz University of South Carolina, Columbia, SC, USA Allergens - structure and function Krzysztof Jozwiak Medical University of Lublin, Poland Structural biology aspects of ligand directed signaling in G-protein coupled receptors Karolina Michalska Argonne National Laboratory, Argonne, IL, USA University of Chicago, Chicago, IL, USA Solute-binding proteins recognizing products of lignin degradation
10:20 – 10:50	Coffee break
10:50 – 12:40	Session VI (Part 1): Enzyme Structures Chair: Alexander Wlodawer Krzysztof Brzezinski Institute of Chemistry, University of Białystok, Poland Structural characterization of microbial S-adenosyl-L-homocysteine hydrolases Grzegorz Bujacz Lodz University of Technology, Poland Polish Academy of Sciences, Poznań, Poland The structural studies of the two isoforms of laccase from the white-rot fungi Pycnoporus sanguineus Miroslaw Cygler University of Saskatchewan, Saskatoon, SK, Canada McGill University, Montreal Quebec, Canada Effector proteins from pathogenic bacteria: focus on kinases Tomasz Cierpicki University of Michigan, Ann Arbor, MI, USA Targeting E3 ligase activity of RING domain with small molecules
12:40 – 12:50	Award of the poster prizes
12:50 – 13:40	Lunch break
13:40 – 15:00	Session VI (Part 2): Enzyme Structures (continued) Chair: Alexander Wlodawer Karolina Majorek Adam Mickiewicz University, Poznań, Poland University of Virginia, Charlottesville, USA Structural and functional characterization of a GNAT acetyltransterase - reproducibility issues Marcin Józef Suskiewicz Vienna Biocenter, VBC, Vienna, Austria The structural investigation of a novel protein kinase class phosphorylating arginine residues Wojciech Rypniewski Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland Crystal structures of chitinases from extremophiles
15:00 – 15:30	Closing session

Organized by: PAN| PTKr| PTPS| RNA-KNOW Poznań| TNW